Biotherapy

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This is one of the most promising new approaches to cancer prevention and treatment and offers great hope to cancer sufferers.

Biotherapy is a therapy for anti-cancer, prevention of disease and anti-ageing.

What is cancer biotherapy? What are its advantages? It is a treatment which uses the body’s own immune system to fight cancer. This therapy stabilizes and balances the body’s anti-cancer response by regulating certain aspects of the natural anti-cancer mechanism of the body resulting in greater cancer prevention and treatment. This therapy has none of the toxic side-effects which result from the use of conventional treatments like radiotherapy and chemotherapy and does not inhibit hemopoiesis – the formation of blood cells in the body. Instead it enhances the body’s immune response.

Treatment Principle

The aim of the treatment is to increase the quantity of T cells which is a major factor in the body’s defense against cancer and also to strengthen the killing function of the T cells. In other words, it is reinforcing the anti-cancer army of the body and equipping it with more combative power.

Main Methods used in Biotherapy:
  1. Anti-cancer cell therapy – adoptive immune therapy such as LAK (lymphokine-activated killer cell) and CIK cell therapy.
  2. Anti-cancer cytotoxic therapy – cytokine therapy such as IL-2, interferon, etc.
  3. Anti-cancer gene therapy – gene vaccine therapy, CEA gene vaccine, P53 gene etc.
  4. Anti-cancer antibody therapy – bio-missile therapy such as heceptin, Glivec, etc.
To elaborate a little on the above methods:

Anti-cancer cell therapy

There is a natural immune mechanism in the human body which is capable of containing and killing malignant cancer cells. However in cancer patients this natural immune function for some reason seems to be impaired or insufficient. In this therapy various cell factors, vaccines and genes are administered with the aim of enhancing the killing effect of the immune cells on the cancer. This therapy forms the basis of other biotherapy methods. There are many kinds of cells in the human body which have an anti- cancer effect. Amongst these the most important one is the T lymphocyte or T cell. The T lymphocyte is one type of white blood cell that attacks virus-infected cells, foreign cells, and cancer cells. T lymphocytes also produce a number of substances that regulate the immune response. T cells are fostered in the thymus gland. Research has shown that T lymphocytes are anti-cancer, anti- disease and anti-aging. The seriousness of AIDS is due to the fact that the AIDS virus destroys T lymphocytes.

LAK cell, CIK and DC cell

LAK stands for lymphokine activated killer. LAK cell is an IL-2 (interleukin-2) activated killer cell . IL-2 is a type of interleukin, a chemical messenger, a substance that can improve the body’s response to disease. It stimulates the growth of certain disease- fighting blood cells in the immune system and is also called cytotoxic T lymphocyte. The characteristics of LAK cells are:

  • A stronger anti-cancer effect than the normal T lymphocyte in the body
  • Has a broad spectrum anti-cancer effect – affects all kinds of cancer cells
  • Does not damage the normal cell
  • Has no toxic side effects
The CIK cell is prepared using the LAK cell as a base. In addition to IL-2, three additional factors are added – CD3McAb, IL-1 and IFN-r. The advantages of this combination are:
  • The proliferation rate is 100 times that of LAK cells
  • The cancer killing effect is 10 times compared to that of LAK cells
  • It affects a broader spectrum of cancer cells and has a stronger killing effect on poly-drug-resistant cancer cells
  • It cannot be influenced by the immune inhibition mechanism.
The CIK cells demonstrate remarkable anti-virus abilities as well. A recent study done by Professor Zhao which was published in the National Medical Journal of China in 2006, (86(26):1823) showed that when hepatocelular carcinoma was treated with CIK cells, the CIK cells were capable of reducing or even eliminating the HBV in the patient’s body. This has the effect of prolonging the remission period of cancer.

DC cell is dendritic cells which can enhance the immune function by presenting the cancer antigen to the cytotoxic T cells. After the CIK cell has been induced with the DC loaded with CEA-rV, the killing effect on CEA positive tumor cell is higher by a factor of 80%.

Treatment Principle

The aim of the treatment is to increase the quantity of T cells which is a major factor in the body’s defense against cancer and also to strengthen the killing function of the T cells. In other words, it is reinforcing the anti-cancer army of the body and equipping it with more combative power. Main Methods used in Biotherapy:
  • Anti-cancer cell therapy – adoptive immune therapy such as LAK (lymphokine-activated killer cell) and CIK cell therapy.
  • Anti-cancer cytotoxic therapy – cytokine therapy such as IL-2, interferon, etc.
  • Anti-cancer gene therapy – gene vaccine therapy, CEA gene vaccine, P53 gene etc.
  • Anti-cancer antibody therapy – bio-missile therapy such as heceptin, Glivec, etc.
To elaborate a little on the above methods:

Anti-cancer cell therapy

There is a natural immune mechanism in the human body which is capable of containing and killing malignant cancer cells. However in cancer patients this natural immune function for some reason seems to be impaired or insufficient. In this therapy various cell factors, vaccines and genes are administered with the aim of enhancing the killing effect of the immune cells on the cancer. This therapy forms the basis of other biotherapy methods. There are many kinds of cells in the human body which have an anti- cancer effect. Amongst these the most important one is the T lymphocyte or T cell. The T lymphocyte is one type of white blood cell that attacks virus-infected cells, foreign cells, and cancer cells. T lymphocytes also produce a number of substances that regulate the immune response. T cells are fostered in the thymus gland. Research has shown that T lymphocytes are anti-cancer, anti- disease and anti-aging. The seriousness of AIDS is due to the fact that the AIDS virus destroys T lymphocytes.

LAK cell, CIK and DC cell

LAK stands for lymphokine activated killer. LAK cell is an IL-2 (interleukin-2) activated killer cell . IL-2 is a type of interleukin, a chemical messenger, a substance that can improve the body’s response to disease. It stimulates the growth of certain disease- fighting blood cells in the immune system and is also called cytotoxic T lymphocyte. The characteristics of LAK cells are:
  • A stronger anti-cancer effect than the normal T lymphocyte in the body
  • Has a broad spectrum anti-cancer effect – affects all kinds of cancer cells
  • Does not damage the normal cell
  • Has no toxic side effects
The CIK cell is prepared using the LAK cell as a base. In addition to IL-2, three additional factors are added – CD3McAb, IL-1 and IFN-r. The advantages of this combination are:
  • The proliferation rate is 100 times that of LAK cells
  • The cancer killing effect is 10 times compared to that of LAK cells
  • It affects a broader spectrum of cancer cells and has a stronger killing effect on poly-drug-resistant cancer cells
  • It cannot be influenced by the immune inhibition mechanism.
The CIK cells demonstrate remarkable anti-virus abilities as well. A recent study done by Professor Zhao which was published in the National Medical Journal of China in 2006, (86(26):1823) showed that when hepatocelular carcinoma was treated with CIK cells, the CIK cells were capable of reducing or even eliminating the HBV in the patient’s body. This has the effect of prolonging the remission period of cancer.

DC cell is dendritic cells which can enhance the immune function by presenting the cancer antigen to the cytotoxic T cells. After the CIK cell has been induced with the DC loaded with CEA-rV, the killing effect on CEA positive tumor cell is higher by a factor of 80%.

Group 5 Years Survival Rate 9 Years Survival Rate
With Biotherapy 54.0% 52%
With only chemotherapy and Radiatherapy 33.4% 22.2%


Biotherapy can prevent the reoccurrence of liver cancer after operation.
Shanghai Liver Cancer Research Institute adopted the use of biotherapy for the prevention of postoperative recurrence of liver cancer in 41 patients. The results were: The one year recurence rate in the routine therapy group was 17.1 % whereas the one year recurence rate in the biotherapy group was only 2.4 %, a very obvious difference. (Chinese Journal of Cancer Biotherapy 1997.4(3):240)

Biotherapy can prolong the survival term of patients with encephaloma. Wuhan Tongji Hospital adopted the use of biotherapy for the prevention of postoperative recurrence of brain glioma. The results were: The biotherapy group (19 cases) Median survival time 38 months The routine therapy group (20 cases) Median survival time 13 months. (The Chinese-German Journal of Clinical Oncology2004:3(3):147-150)

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