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Case Studies

You are here :: Home » Case Studies

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1. Acute Myeloid Leukemia
2. Synovial Sarcoma
3. Biotherapy miracle - Advanced Stage Breast Cancer
4. Laryngocarcinoma
5. Lung Cancer
6. Metastasized Lung Cancer
7. Liver Cancer
8. Liver Cancer
9. Liver Cancer
10. Breast Cancer
11. Multiple Myeloma
12. Peritoneal Mesothelioma

Case Study 1:

Biotherapy Case Study - Patient with Acute Myeloid Leukemia

Name: Mdm. Wong Muh Keng
Country: Malaysia
Age: 55
Diagnosed with AML - Acute Myeloid Leukemia in Jun 2007. Had 4 rounds of chemotherapy until January 2008 in a local hospital.

Came to our hospital for Biotherapy on 20 May 2008. Started course of biotherapy on the 22 May 2008. After one treatment her husband already noticed that she was standing up straighter and had a lot less back pain. She had more energy and was not puffing and panting so much when going for a walk.

After the second treatment, her finger nails, soles of her feet, her face were not so pale looking. She felt more energetic and alert.

On the last day of the treatment, she reported that she was able to recite all her prayers in one sitting. She was not able to do so before as she used to run out of breath. She was able to go up and down the stairs without feeling breathless. She looked pink and well.

3 July 2008
She happily reports that her haemogram is that of a normal person, unlike before the treatment and gives her consent for use of her name in our website. November 2008
She had a bone marrow test done. All indicators are normal.

Click here to link to Biotherapy information page.

More to come.....

We take pride in delivering world-class medical treatments to all of our patients. We are in the process of collecting data on all the past cases and having them translated and collated so that you can share in our proud achievements and in a new hope for a better future.

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Case Study 2:

Synovial Sarcoma Name: Ms Li
Diagnosis upon admission: Synovial Sarcoma
Age: 25
Country: Indonesia.


Diagnosis upon admission: Synovial Sarcoma Case history:

2004 Accidentally discovered a lump on the inner side of the right thigh. Did not pay much attention to it. 2005 September after travelling, noticed that the right lower limb was swollen. Shenzhen hospital B-ultrasound examination:size of growth was 9.3*7.3*7.3cm 2006 January recurrence of stronger symptoms. MRI examination: Huge soft tissue growth on the inner side of the right thigh - size about 11.7*8.6*11.1cm. Considered as malignant tumour.

2006 February Singapore General Hospital needle biopsy: well differentiated synovial sarcoma. Immunohistology: Keratin (+), EMA(+), calponin (+). 4 rounds of chemotherapy with resulting hair loss, gastrointestinal reactions, inhibition of bone function.

2006 May 30 MRI re-examination: Tumour size about 14.6*11.4*8.2. Did not accept doctor's suggestion of radiotherapy and surgery.

Diagnosis upon admission to You Hao Hospital:
Both thighs are not symmetrical. Right thigh has local swelling, Veins were prominent on the facies ventralis of the right thigh and calf. A tumour of size 15*12cm could be felt on the inner side of the right thigh of little mobility, hard, no pain when pressed, non fluctuating, 27 cm from the inferior margin of the hip bone measurement of circumference of right thigh was 59.5 cm, left thigh 53.5cm, no water retention in both lower limbs.

Course of treatment:
HIFU treatment for the tumour, I 125 brachytherapy - short range interstitial radiation - for the synovial sarcoma. 2006 July 16 right thigh had gone done in size, the circumference was 56cm, was softer, no other unusual symptoms. Discharged from hospital. 2006 aug 18 Underwent I 125 brachytherapy - short range interstitial radiation treatment at the hospital for strengthening the treatment.

Condition after treatment:
2007 January 16 Came back to hospital for re-examination. No unusual symptoms. 27 cm from the inferior margin of the hip bone measurement of right thigh was 54.5cm. Now leading a good normal life working.

More to come.....

We take pride in delivering world-class medical treatments to all of our patients.
We are in the process of collecting data on all the past cases and having them translated and collated so that you can share in our proud achievements and in a new hope for a better future.

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Case Study 3:

Last Stage Breast Cancer
Name: Mrs. XXX
Country: Anyang, China
Age: 36

Oct 2006 Admitted to Henan XXX Tumour Hospital. Diagnosed with cancer of left breast. Underwent modified radical mastectomy. Dec 2006 underwent TA chemotherapy 4 cycles . April 2007 discovered tumour above left clavicle. Needle biopsy revealed metastasis in mammary gland lymph nodes.

Also discovered metastasis in both lungs and mediastinum. Underwent Chemo again but was not found to be effective. Disease continued to worsen with emergence of pleural effusion. The doctors advised her to seek treatment elsewhere. June 2007 she arrived at the hospital for treatment.

Pathological diagnosis on admission to You Hao hospital: Poorly differentiated adenocarcinoma of the left breast, Partly clear cell carcinoma, partly medullary carcinoma, Vascular invasion. Immunohistochemical staining test results: ER(+), PR(+), CERBB-2 (+++), CA15-3 (++) with Metastases in both lungs, mediastinum, upper left clavicular lymph nodes, And Fluid retention in the thoracic cavity.

Treatment:
Due to the fact that the disease was in a very advanced stage and chemotherapy was no longer a viable option, the specialists proposed the use of biotherapy. After one course of conventional biotherapy treatment (cord blood CIK) the patient reported less chest pain, less chest distress, and the clavicular mass showed significant reduction in size. However after half a month the supraclavicular lymph node tumours showed enlargement. The second round of biotherapy did not result in much obvious improvement. The patient displayed symptoms of taking a turn for the worse. There was increased pleural effusion, chest pain, unable to lie flat on her back during sleep, required pleural effusion drainage every 2-3 days. Increased metastatic foci in the lungs, infringement on the bronchial tubes. Severe coughing day and night, unable to sleep at night. Poor appetite, weak, did not even have the strength to get out of bed.

23 July 2007 PET/CT scan showed:
1) Recurrence and metastasis of cancer after modified radical mastectomy of left breast and chemotherapy. Had nuclear implantation done.
Wide recurrence of cancer in the left chest wall. 2) Diffuse metastasis in both lungs, and both sides of the thymus with medium quantity of dropsy.
3) Multiple metastasis in lymph nodes above both clavicles, beneath left armpit, in bilateral porta pulmonis, and mediastinum.
4) Systemic multiple metastases in bones.

Clinical symptoms and examinations indicated that the disease was at a very advanced stage. The doctors felt that at any time there was mortal danger to the patient. They did not have any options except to advise the patient to return home to Anyang as soon as possible.

Miraculous turnaround
From Guangzhou to Anyang by train is a 20 odd hour journey. For the safety of the patient, the doctors planned to drain out the fluid from the chest before discharge from the hospital and considered to do biotherapy one more time to improve the condition of the patient for her safe return to her hometown. Upon admission to the hospital it was discovered upon examination that the patient’s immunocyte count was 1195/µl and that of her husband’s was 3242/µl which was almost 3 times as much. The doctors decided to try out a new method of preparing the biotherapy medicine – that of using the husband’s immunocytes for the preparation of the CIK treatment for the patient. Till then this method was yet unreported anywhere within China and abroad. It was a bold attempt and resulted in a miracle. 26 July 2007 For the first time for the patient and very possibly in the medical history of China, healthy adult blood was used in the preparation of CIK and was administered. 27 July 2007 morning 8am during ward visit: The patient showed marked improvement in alertness and energy levels, reported less coughing during the night – only 3 times and had improved sleep during the night before. 29 July 2007 conclusion of biotherapy treatment. The response of the patient was extremely positive. The coughing had almost disappeared. Patient was able to sleep well. Appetite singnificantly improved. First time in a month that patient was able to get out of bed to tidy the room and to cook a meal. The medical doctor in charge remarked that of all the cases receiving CIK biotherapy treatment that this was the best they had seen. Under the positive influence of the biotherapy treatment the patient arrived home in Anyang safely. Because we were not familiar with the results of using healthy adult blood for CIK treatment and the patient had seemed to be on the verge of death, we had asked the family to be mentally prepared for the worst. Under normal circumstances, the survival period would not be more than 3 months. After returning home to Anyang the patient had her funeral arrangements made. Relatives came to visit to bid farewell. As our hospital did not hold out any hope for her, in the ensuing 3 months we did not follow up with her.

Unexpected good news emerged. On 19 September 2007 Professor Dr. Qi suddenly received a call from the patient saying she had recovered and had left the hospital. He could not believe his ears. On further questioning she revealed that in July upon returning home she had checked into the local hospital. In July, August September, the monthly CT scans had showed increasing improvement in her condition. The metastatic foci in the lungs and pleura had all disappeared. The metastases in the mediastinum had decreased in size significantly. 6 October 2007 CT scans reveal absence of metastatic foci in the chest, metastases in the mediastinum had completely disappeared. The patient was mentally and physically very well. 2 November 2007 Came to Guangzhou for a PET/CT scan re- examination: Metastasis after surgery and chemotherapy. After subsequent comprehensive treatment: (1) most of the tumours in the left chest wall have disappeared, metabolism reduced significantly indicating significant therapeutic effectiveness. (2) the original pervasive metastasis in both lungs have basically disappeared, the original pleural effusion in both lung has been completely absorbed. (3) The original multiple metastases in the lymph nodes above the clavicles, underneath the left armpit, in both porta pulmonis and mediastinum have largely disappeared. (4) Multiple metastasis in T 10, 11, 12, 14 and right iliac bone.

The patient when we last contacted her is back at work.

Click here to link to Biotherapy information page.

More to come.....

We take pride in delivering world-class medical treatments to all of our patients. We are in the process of collecting data on all the past cases and having them translated and collated so that you can share in our proud achievements and in a new hope for a better future.

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Case Study 4:

Laryngocarcinoma

Name: Mr. Zhang
Country: Indonesia
Age: 57
Diagnosis upon Admission:
Squamous carcinoma of left larynx, IV stage. Anterior of neck chronic carcinoma with abscess and infection.
Medical History:
2002 repeated instances of sore throat. Took oral medication for pharyngitis. Got cured. 2003 another outbreak. Laryngoscopy revealed laryngeal tumour. Did not have operation. 2004 May Because of the severity of pain, used laser surgery for tumour removal. Pathological findings: tumour was benign. After surgery hoarseness of voice. Took herbal medicine on and off as treatment. 2006 April – emergence of headaches, pain in the right side of neck. Thyroid cartilage had reddish swelling with pus being issued. 2006 June 1 Breathing difficulties, wheezing. Recent loss of weight.

At time of admission, was suffering from shortness of breath, presence of a carbuncle, an approximately 3*4cm reddish mass at the anterior of the thyroid cartilage with many pus spots. When pressed, oozed yellowish green viscous pus. CT scan: left lateral laryngocarcinoma (glottis area), involving cartilagines laryngis, right lateral vocal chords and superior and inferior parts of glottis.

Treatment:
After admission to hospital, surgical incision to drain pus from and disinfect carbuncle. 2006 June 26 Start of chemotherapy. 2006 July 7 performed percutaneous I¹²5 particles implantation (short distance radiotherapy) for laryngocarcinoma. 2006 July 18 significant reduction in size of incision on anterior of neck to approximately 1.5*1 cm, reduction of sphacelus and growth of bright red sarcolemma tissue. Discharged from hospital. 2006 August 10 Admitted to hospital for re-examination: left laryngocarcinoma tumour reduced in size. Performed additional brachytherapy with I¹²5 particle implantation for left laryngocarcinoma and second round of whole body chemotherapy. 2006 November 20 Admitted to hospital for third round of whole body chemotherapy.

Condition after treatment: Living a normal life.

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Case Study 5:

Lung Cancer

Name: Mdm. Li
Country: Taiwan
Age: 74
Diagnosis upon Admission:
Squamous cell carcinoma of left lung.
Medical History:
2007 Feb discovered left upper part of lung had a lesion occupying 6 cm in diameter. Using brochofiberscope the diagnosis was non small cell lung cancer III stage.

Condition at admission:
Laboratory tests:
CEA 0.45ng/ml, CA125 33.61 U/ml, CA153 108.57 U/ml, NSE 5.1 ng/ml, CF211 8.68 U/ml.

Treatment:

Localised treatment for the tumour using transcutaneous arterial chemoembolism. 1 course of biotherapy to strengthen the immune system.
2007 April 23 CT guided I¹²5nuclear implantation(brachtherapy) on the left lung was performed under general anaesthesia.
Condition after treatment:
Living a normal life.

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Case Study 6:

Lung Cancer Metastasized

Name: Mdm. Fung
Country: Guangdong, China. Town of Shunde.
Age: 59
Diagnosis upon Admission:
Cancer of the right lung with metastasis to L5.


Medical History:

2006 June for no obvious reason had numbness and pain in the right leg and back pain. Got treated at the local hospital for slipped disks in L4, 5. No obvious improvement. 2007 July CT scan: lesion in the base of the lower lobe of the right lung with metastasis to the right porta pulmonis and lymph nodes in the mediastinum. Focal lesion in L5 indicated high metabolism. Bronchofiberscope examination. Needle biopsy of right inferior lung conforms to papillary adenocarcinoma. 2007 August PET/CT scan examination: cancer of inferior right lung, metastasized to L5 and subscapular bones.

Condition at admission:
CEA: 77.16
CA153:46.28
The rest is as before.


Treatment:
2006 August 10 I¹²5nuclear implantation (brachtherapy) for right lung cancer, metastatic foci in L5 and subscapularis. 2006 August 15 start of 2 rounds of whole body chemotherapy.
2006 October 21 One more round of Brachytherapy for the lung cancer and L5 vertebra.

Condition after treatment: Now living very normally.

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Case Study 7:

Liver Cancer Name: Mr. Deng
Physical Education teacher in secondary school.
Age: 36
Diagnosis upon Admission:
Liver cancer.
Medical History:
Admitted to hospital due to weight loss, lack of appetite for about 3 months, bloatedness in liver region.

Examination upon admission:
AFP 90.81ng/L.
CT scan and ultrasound: lesion in right lobe of liver.

Treatment:

2006 October 12 localised chemotherapy and arterial embolism (transarterial chemoembolism) 2006 October 30 performed I¹²5 interstitial radiotherapy for the liver cancer.

Condition after treatment: Living and working normally.

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Case Study 8:

Liver Cancer

Name: Mr. Lu
Sports trainer in Beijing
Age: 62

Diagnosis upon Admission: Liver cancer

Medical History:
2006 December 14: Physical examination, B ultrasound and antibodies. Diagnosed by Peking Union Medical College Oncology Hospital as liver cancer. 2006 Dec 26 and 2007 Feb 1 underwent transcutaneous arterial chemoembolism.

Condition upon admission:
Good general condition. Indication from B-ultrasound: Right side of liver and gallbladder uneven echo 3.3*4.5, laboratory tests: ALT:2.2, AST:60.6, ALP:102.2, AFP:16.35, CEA:0.52.

Treatment:
2007 Mar 31 performed I¹²5particle implantation using 50 particles . Discharged from hospital 5 days later.

Condition after treatment:
Currently very well.

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Case Study 9:

Liver Cancer

Name: Mr. Jian from Gaoxiong City, Taiwan
Age: 54
Diagnosis upon Admission: Liver cancer
Medical History:

2006 October B ultrasound and CT discovered a lesion with diameter size of 1.2cm. 2006 December had a needle biopsy of the liver tumour, liver cancer according to pathological diagnosis. Was treated with Chinese patent medicine at the local hospital for 3 months. 2007 February CT reexamination: tumour size about 3.2cm.

Condition upon admission:
Heart, lungs and stomach normal. Liver-spleen subcostal no metastasis. Lab results: Glu: 8.41mmol/l, ALT: 82u/l, AST:54.5 u/l, ALP: 118.5u/l, HbsAg: +ve, HbeAb: +ve, HbcAb: +ve. No other remarkable results.

Treatment:
2007 April 4 Under CT guidance and local anaesthesia, thirty I¹²5 particles were implanted together with injection of 5-FU, DDP, Lipiodol ultra-fluid, absorbable gelatin sponge. After the operation administered anti-inflammation, haemostatic and support therapies. One course of biotherapy.

Condition after treatment: Living well.

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Case Study 10:

Breast Cancer

Name: Mdm. Ho from Singapore
Age: 36
Diagnosis upon Admission: Breast cancer


Medical History:

2002 bleeding from the right nipple. Mammography did not indicate any abnormality. 2003 Appearance of a lump about the size of a soybean inside the medial inferior quadrant of the right breast, was hard, not very mobile, gradually enlarging, no treatment. 2005 size increased to about 3.5 cm. 2005 May had a surgery to remove the tumour. Was found to be malignant. Doctors suggested to have a radical mastectomy done. Patient refused and sought treatment at our hospital.

Treatment:

2005 June underwent I¹²5 nuclear particle implantation (brachytherapy) and transcutaneous arterial chemoembolism for the right breast tumour and surrounding lymph nodes underneath the armpit and above the right clavicle. After the operation continued on hormone therapy.

Condition after treatment:

Subsequent reexamination till now, no metastasis locally or elsewere.
2007 Sept PET/CT scan indicated no appearance of abnormality.

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Case Study 11:

Multiple Myeloma

Name: Mdm Dai
Age: 53
Diagnosis upon Admission: multiple myeloma


Medical History:

2004 October Because of tumors in the bone all over the body, patient fell down several times and easily suffered bone fractures. As a consequence was admitted to the orthopedic department of various hospitals for treatment but with no obvious improvement. After ECT and CT examinations was diagnosed as multiple myeloma. After unsuccessful treatment at several hospitals patient was admitted to our hospital.

Condition upon admission: CT and X ray examinations: damage to thoracic bones, lumbar bones, cranium and pelvic bones. Had to use morphine to control the pain with no obvious results.

Treatment:

2005 March under CT guidance implanted I¹²5 nuclear particles to the various areas of the bones which were damaged. 5 days later there was obvious lessening of the pain in the bones and there was no need for medication for pain or fever.

Condition after treatment:

2005 March 29 from medical reexamination and feedback from the patient the condition showed obvious improvement. 2005 May till now, bone marrow and biochemical indicators have shown that the condition has been completely alleviated, patient has freedom of movement and is able to lead a normal life. At specified intervals, appropriate amounts of chemotherapy are used. Patient is living well.

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Case Study 12:

Peritoneal Mesothelioma

Name: Mr. Lee
Age: 38


Medical History

Mr. Lee had suffered from cancer (peritoneal mesothelioma) for 5 years. He had been treated in several hospitals including undergoing surgery 4 times but without much satisfactory results and his condition continued to deteriorate. At the end of 2004 a CT scan revealed that there were multiple metastases in the liver and extensive metastasis in the abdomen. The patient had been bedridden for half a year and was considered hopeless by other hospitals. However, the family of the patient did not give up hope and sought treatment at our hospital in March 2005.

Condition upon admission

At the time of admission the patient was in a very debilitated condition. He was very skinny but with abdominal distension. An irregular size hard lump was found under his right rib. His lower limbs suffered serious water retention. He was short of breath and he was not capable of movement.

After Treatment

Under our expertise and comprehensive care with the adoption of a multifaceted approach to treatment combining HIFU with Chemotherapy and Biotherapy the patient showed a miraculous turnaround after a month. Shortness of breath, ascites and edema in the lower limbs were all gone! The lump under the rib had become soft and smaller. His appetite was strong and his face and weight had come back to normal. He could completely take care of himself and could go out for walks and activities outside.

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